Low levels of dopamine were found to stimulate adenylate cyclase from the striatum, median eminence, olfactory tubercle, nucleus accumbens and amygdala. Show more Neurotransmitters and Anterior Pituitary Function discusses research findings on neurotransmitter-neurohormone interactions in the control of the anterior pituitary. The results presented here demonstrate a new instance where an opiate antagonist modifies normal function. There was no difference between the groups in the hypoglycaemia which developed. This new compound has been tested for its pharmacological actions both in vitro and in vivo. Plasma prolactin levels in the rat are elevated by reserpine treatment.
This book contains five chapters that specifically tackle the most salient constituents of the neural-endocrine communication system in mammals. This book contains five chapters that specifically tackle the most salient constituents of the neural-endocrine communication system in mammals. Exposure of the 4 cultures to fresh medium containing bromocriptine for an additional 3 days resulted in a further inhibition of prolactin secretion. Fifteen neuroleptics of the phenothiazine, thioxanthene, dibenzazepine, butyrophenone or diphenylbutylamine type were studied in rats. It is less than 20 years that the problem of the separate identity of human and monkey prolactins was posed with the observations of Lyons et al. Fifteen days after surgery, 0.
Several neurally active amino acids were injected into the third ventricle of anesthetized male rats. A chapter highlights both traditional and a vast series of developed drugs that affect both neurotransmitter and neuroendocrine function. Using naltrexone as a tool to block opiate receptor function, we have explored whether endorphins are tonically involved as a putative neurotransmitter in the regulation of prolactin release. Such connections are suggested from lateral and posterior hypothalamus onto the medial basal nuclei. Brain Catecholamines and Drug Therapy for Endocrine Disorders Bibliography Index. Table of Contents Preface List of Abbreviations I Neurotransmitters and Neurohormones A.
A further significant increase P less than 0. The calculated inhibition constant Ki for loxapine of about 15 nM was similar to that observed for some of the more potent phenothiazines. A single dose of 0. In those who show a full response of G. Responsive sites were distributed in ventral and dorsal medial hypothalamus and extended into the thalamus. Not only the median eminence but also the nuc. Bloom, personal communication in hypothalamic neurones indicated that neuroendocrine effects are probable.
At all doses used 0. Clonidine, an alpha-adrenergic stimulating drug, elevated prolactin levels whereas the beta-adrenergic stimulator isoproterenol had no effect. Mecamylamine a nicotinic blocker produced a small transient elevation in plasma prolactin. Clinical neuroendocrinologists and researchers and students in neuroendocrinology, neurobiology, neuropharmacology, neurophysiology, and psychiatry will find this book invaluable. A chapter highlights both traditional and a vast series of developed drugs that affect both neurotransmitter and neuroendocrine function. Summary Neurotransmitters and Anterior Pituitary Function discusses research findings on neurotransmitter-neurohormone interactions in the control of the anterior pituitary.
Phenoxybenzamine, an alpha-adrenergic blocker, at high doses, increased plasma prolactin. Insulin tolerance tests have been performed on 12 patients with Huntington's chorea and 10 controls. Blockade of dopaminergic or alpha-adrenergic receptors by pretreatment with pimozide Pim or phentolamine Phent , respectively, or central sympathectomy by intraventricularly i. Morphine was previously reported to block ovulation, while more recently, morphine11 and endorphins12-14 were observed to stimulate release of prolactin and growth hormone. The present report is a comparative study of adenylate cyclase activity in various areas of the brain identified as dopaminergic. In this study we report that ether stress which produces prolactin release in normal rats was equally effective in stimulating prolactin release in reserpine treated animals whose initial baseline prolactin levels were elevated.
Bromocriptine may also be used with benefit in the large number of patients who have shown a partial response to other forms of therapy. L'activité inhibitrice de la prolactine dans le plasma de la tige hypophysaire peut Être le résultat d'un facteur particulier, et la sécrétion de ce facteur serait gouvernée par un mécanisme «dopaminergique». Bromocriptine did not block stress-induced G. Others have shown that suckling releases prolactin through an excitatory serotonergic mechanism. Neurotransmitters and Anterior Pituitary Function discusses research findings on neurotransmitter-neurohormone interactions in the control of the anterior pituitary. Discussions then shift to the experimental evidence on pituitary function control by the brain through releasing and inhibiting hormones secreted by hypothalamic neuroendocrine cells; the chemical isolation, identification, and synthesis of hypothalamic neurohormones; and concepts of their mechanism of action at the level of the pituitary cells.
Several different classes of drugs effective in the treatment of schizophrenia were potent inhibitors of the stimulation by dopamine of the enzyme from these various regions. A chapter highlights both traditional and a vast series of developed drugs that affect both neurotransmitter and neuroendocrine function. The central monoamine terminals thus have the same characteristic appearance as the adrenergic synaptic terminals in the peripheral nervous system. Levels of plasma prolactin were estimated in ovariectomized, estrogen-treated rats following the systemic administration of several neural blocking and stimulating drugs. It did not distrub pituitary function other than secretion of prolactin and had negligible side-effects. This fraction was purified further by six steps involving chromatography on Sephadex G-25, countercurrent distribution, free-flow electrophoresis, and chromatography on triethylaminoethyl cellulose.